R. D. Boehm
B. Chen
S. D. Gittard
B. N. Chichkov
N. A. Monteiro-Riviere
A. Nasir
R. J. Narayan

Two-photon polymerization/micromolding of microscale barbs for medical applications

Journal of Adhesion Science and Technology
3-4
28
387-398
2014
Type: Zeitschriftenaufsatz (reviewed)
Abstract
Tissue barbs are small-scale structures that may be used for sutureless joining of tissues. In this study, several types of tissue barbs were fabricated using two-photon polymerization/micromolding, including two-pronged tissue barbs, eight-pronged tissue barbs, 10-pronged tissue barbs, and 16-pronged tissue barbs. Tissue barb penetration in porcine tissue was observed using confocal laser scanning microscopy. Constructs containing medical tape and tissue barbs were created by applying tissue barbs in a parallel arrangement to Transporeā„¢ medical tape. These results suggest that two-photon polymerization/micromolding is an indirect rapid prototyping approach that may be used for high-throughput replication of tissue barbs and other microstructured solid wound sealants.