P. S. Timashev
D. Kuznetsova
A. V. Koroleva
N. Prodanets
A. Deiwick
Y. Piskun
K. N. Bardakova
N. Dzhoyashvili
S. Kostjuk
E. Zagaynova
Y. A. Rochev
B. N. Chichkov
V. N. Bagratashvili

Novel biodegradable star-shaped polylactide scaffolds for bone regeneration fabricated by two-photon polymerization

Type: Zeitschriftenaufsatz (reviewed)
AIM: To assess the properties of 3D biodegradable scaffolds fabricated from novel star-shaped poly(D,L-lactide) (SSL) materials for bone tissue regeneration. MATERIALS & METHODS: The SSL polymer was synthesized using an optimized synthetic procedure and applied for scaffold fabrication by the two-photon polymerization technique. The osteogenic differentiation was controlled using human adipose-derived stem cells cultured for 28 days. The SSL scaffolds with or without murine MSCs were implanted into the cranial bone of C57/Bl6 mice. RESULTS: The SSL scaffolds supported differentiation of human adipose-derived stem cells toward the osteogenic lineage in vitro. The SSL scaffolds with murine MSCs enhanced the mineralized tissue formation. CONCLUSION: The SSL scaffolds provide a beneficial microenvironment for the osteogenic MSCs' differentiation in vitro and support de novo bone formation in vivo.