L. Gentemann
S. Kalies
M. Coffee
H. Meyer
T. Ripken
A. Heisterkamp
R. Zweigerdt
D. Heinemann

Modulation of cardiomyocyte activity using pulsed laser irradiated gold nanoparticles

Biomedical Optics Express
1
8
177-192
2017
Type: Zeitschriftenaufsatz (reviewed)
Abstract
Can photothermal gold nanoparticle mediated laser manipulation be applied to induce cardiac contraction? Based on our previous work, we present a novel concept of cell stimulation. A 532 nm picosecond laser was employed to heat gold nanoparticles on cardiomyocytes. This leads to calcium oscillations in the HL-1 cardiomyocyte cell line. As calcium is connected to the contractility, we aimed to alter the contraction rate of native and stem cell derived cardiomyocytes. A contraction rate increase was particularly observed in calcium containing buffer with neonatal rat cardiomyocytes. Consequently, the study provides conceptual ideas for a light based, nanoparticle mediated stimulation system.