Biophotonics Group

  • High-throughput cell transfection

  • Multi-photon microscopy

  • Laser-optical cochlea stimulation

  • Optogenetics

  • Endoscopic imaging using Optical Coherence Tomography (OCT)


The specific optical manipulation of biological systems on the cellular level is the core work area of the Biophotonics Group. Biomedicine is the main application field for their work. For example cellular structures can be removed using  the laser in order to carry out functional studies about regeneration or to enable the introduction of extracellular molecules. Combined with gold nanoparticles, this approach can be used as a method for high-throughput cell transfection. On the other hand, within the scope of the so-called optogenetics proteins that can be guided by light are introduced into the target cell. With these proteins it is possible to control cellular functions precisely. Thus, for example a light impulse can cause muscle cells to contract. Another field is optoacoustics. Here, short laser pulses cause pressure waves that the hair cells of the inner ear can convert into a hearing impression.

Besides the stimulation, the group deals with non-linear microscopy for the visualization of biological processes. Due to the simultaneous absorption of several photons, different structures of biological tissue can even be visualized without prior dyeing. In that way, among others, various bacteria species can be identified within one biofilm.

Based in the NIFE - Lower Saxony Centre for Biomedical Engineering, Implant Research and Development, the Biophotonics Group has direct access to partners in the field of biomedicine and material research.

Focus of Work

  • Design and development of the Scanning Laser Optical Tomography (SLOT)
  • Marker-free imaging using tissue-optical contrast mechanisms
  • Large-scale volumetric imaging of functionalized implants
  • Implant research
  • Optical coherence tomography (OCT)
  • Time-resolved imaging of the laser-tissue interaction