Image Guided Laser Surgery Group

Experimental setup for measuring the refractivity of eye lenses during simulated accommodation
Optical coherence tomography (OCT) of a porcine vocal fold
fs-laser cut pattern in a porcine eye
Short-time photography of two cavitation bubbles in water resulting from focused fs-laser pulses

Main Work Areas

  • Imaging using optical coherence tomography (OCT)
  • Exogen-dye-free laser microscopy Lasermikroskopie
  • OCT-image-guided eye surgery using fs-lasers
  • High-speed photography of laser-tissue interaction
  • Focus forming using adaptive optics
  • Laser-optical stimulation in the cochlea
Current Scientific Activities and Projects

Investigations on pulse-to-pulse interaction for optimizing cutting of highly-repetitive fs-laser systems for medical applications  (DFG):

  • Optimization of fs-laser applications on biological tissue
  • Influence of pulse-overlapping of modern laser systems on the cut quality
  • Short-time photography of cavitation bubble interaction
Investigation of the accommodation behavior of the eye lens after femtosecond-laser induced cutting (DFG):
  • Increasing the accommodation distance
  • Finite-Element-Simulation and experiments
  • OCT-control of cutting in a lens stretcher
Transregio SFB 37 Project A5: Optically induced excitation of the cochlea. Development of an opto-acoustic actor  with nanosecond resolution for the cochlea.
  • Cochlea implant with laser-optical stimulation
  • Opto-acoustic or neuronal interaction
  • Application parameters and applicatior design
Transregio SFB 37 Project Q1: Optical multimode in vivo imaging of cellular, intra and peri-implant processes:
  • 3-D microscopic presentation of anatomy, function and metabolism of cellularized micro- and nanostructures and their environment
  • Multi-photon microscopy, in-vivo confocal laser scanning microscopy, optical coherence tomography
Innovative cataract, presboypia, and retina treatment using ultra-fast lasers - IKARUS (BMBF):
  • Prototype for the treatment of cataract and presbyopia
  • OCT image-assisted cutting
  • Adaptive optical focus forming for vitreo-retinal cuts
Setup and testing of a motion compensating method for OCT-assisted layngoscopy (Aif/BMWi):
  • Combination of video-laryngoscopy and OCT
  • Autofocus and motion compensation
  • OCT laryngoscopy on a patient without the use of anesthetics

Head of Group

Dr. rer. nat. Alexander Krüger
Phone: +49-(0) 511 2788-227
E-Mail: a.krueger@lzh.de